Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery
نویسندگان
چکیده
منابع مشابه
Association between shortened leukocyte telomere length and cardio-metabolic outcomes.
In their meta-analysis of 27 published studies, D’Mello et al show that shortened leukocyte telomere length (LTL) is associated with 3 primary end points: myocardial infarction, stroke, and type 2 diabetes mellitus. The meta-analysis and its findings raise several fundamental issues that are worth considering. After discussing the major findings and limitations, we focus on 3 central themes: th...
متن کاملLeukocyte telomere length: the telomere tale continues.
In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
متن کاملHomocysteine levels and leukocyte telomere length.
OBJECTIVE Elevated plasma homocysteine is a risk factor for vascular diseases, possibly due to homocysteine-mediated increase in oxidative stress and inflammation. As leukocyte telomere length (LTL) registers the cumulative oxidative stress and inflammation, we examined the relationship between homocysteine and LTL. METHODS LTL was measured using the Southern blot method. The relationship bet...
متن کاملLeukocyte telomere length and cardiovascular disease in the cardiovascular health study.
The telomere length of replicating somatic cells is inversely correlated with age and has been reported to be associated cross-sectionally with cardiovascular disease (CVD). Leukocyte telomere length, as expressed by mean terminal restriction fragment (TRF) length, was measured in 419 randomly selected participants from the Cardiovascular Health Study, comprising a community-dwelling cohort rec...
متن کاملOriginal Contribution Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
1 Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 2 Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 3 Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, Newark, NJ. 4 Department of Medicine, School of Medicine, University ...
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ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2018
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2018.07.004